| Insert |
DNA: genomic Insert lengths(kb): 16.0 Tissue: liver Gene product: DNA Segment, single copy [D5S59] Alleles: A1, A3, B1, B2, B3, A2 |
| Comments |
Restriction digests of the clone give the following sizes (kb): BamHI--23.0, 12.0, 5.4, 3.7; SmaI-->23.0, 8.7; HindIII--23.0, 12.0, 6.0, 2.9; PvuI--23.0, 14.0, 5.0, 2.4; EcoRI--20.0, 16.0, 14.0. The PstI and MspI polymorphisms have a combined PIC value of 0.50 and a combined heterozygosity of 60%. Enzyme(s) not detecting polymorphism: HincII, RsaI, TaqI, BglII (panel of 5 individuals). |
| References |
Schumm JW, et al. Identification of more than 500 RFLPs by screening random genomic clones. Am. J. Hum. Genet. 42: 143-159, 1988. PubMed: 2892396
Donis-Keller H, et al. A genetic linkage map of the huma genome. Cell 51: 319-337, 1987. PubMed: 3664638
Jacobsen SJ, et al. A clinically homogeneous group of families with facioscapulohumeral (Landouzy-Dejerine) muscular dystrophy: linkage analysis of six autosomes. Am. J. Hum. Genet. 47: 376-388, 1990. PubMed: 1975474
Weiffenbach B, et al. A genetic linkage map of human chromosome 5 with 60 RFLP loci. Genomics 10: 173-185, 1991. PubMed: 1675192
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